A/G RATIO
The A/G ratio is the ratio of albumin to globulin, and along with fibrinogen (produced by the liver) literally measures the thickness or “collagen factor” of the blood.
The A/G ratio then is also a representation of the fibrinogen content in the blood and regulates the amount of protein being utilized at any time in the body.
The liver forms prothrombin, which requires vitamin K. for its production. Prothrombin is a plasma protein, which is changed into thrombin via prothrombin activator and calcium.
Thrombin, transposes fibrinogen into fibrin, continually causing clotting throughout the body along with blood platelets.
Fibrinogen, therefore, provides the clotting thickness (collagen factor) in the blood.
These polarized protein fibrous strands are necessary to maintain blood viscosity, which regulates the amount of capillary exchange from the artery to the extracellular fluid.
Collagen a protein strand (albuminoid) and proteoglycan filaments also regulate exchange by causing a very slow diffusion of molecules via kinetic motion moving substances through the extracellular fluid either to the cell membrane or back into the circulatory or lymphatic systems.
Collagen is also the main structural protein in connective tissue and found in the extracellular spaces. Collagen and proteoglycan filaments are used in the interstitium to provide tensile strength and for healing.
As the main component of connective tissue, it makes up from 25% to 35% of the whole-body protein content. Collagen is formed in the sternum and iliac crest.
A/G RATIO IS INCREASED WHEN
Anything that would decrease globulin would increase the A/G ratio and anything that would increase albumin would also increase the A/G ratio so also look at all the possibilities under low globulin or high albumin
THE A/G RATIO IS DECREASED WHEN
Anything that would increase globulin would decrease the A/G ratio and anything that would decrease albumin would decrease the A/G ratio so also look at all the possibilities under high globulin or low albumin
