SEGMENTED NEUTROPHILS/POLYS/GRANULOCYTES
SEGMENTED NEUTROPHILS Are the most numerous and most important WBC's since they form the first line of defense via phagocytosis against infection and microbial invasion. Immature neutrophils are called stab or band cells. Neutrophils also release enzymes called endogenous pyrogens, which can also cause tissue damage.
ABSOLUTE COUNT 3,000-7,000 mm3
DIFFERENTIAL 50% OT THE TOTAL WBC's
Increased neutrophils (neutrophilia >8,000 mm3) is found in:
1. Bacterial, viral, fungal, spirochete and parasitic infections
2. Inflammatory diseases such as rheumatoid arthritis, pancreatitis, gout
3. Tissue necrosis from burns, tumors
4. Diabetes mellitus
5. Uremia
6. Hepatic necrosis
7. Malignant neoplasms
8. Myeloproliferative diseases such as polycythemia vera, myeloid leukemia
9. Lead, mercury, digitalis, snake venoms
Decreased neutrophils (neutropenia <1,800 mm3) are found in:
1. Inherited stem cell disorders
2. Acute bacterial infections
3. Viral infections (mono, hepatitis, measles
4. Rickettsial and parasitical infections
5. Drugs
6. Hematopoietic diseases Many of your anemias
7. During inflammation (first 24-48 hours)
8. Allergic
9. Toxic reactions
****Agranulocytosis is a marked neutropenia and leukopenia, which leaves the person open to life-threatening infections.